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Article

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.

The Journal of clinical investigation - 1 Nov 2004

Ling Charlotte, Poulsen Pernille, Carlsson Emma, Ridderstråle Martin, Almgren Peter, Wojtaszewski Jørgen, Beck-Nielsen Henning, Groop Leif, Vaag Allan

Abstract excerpt

Genetic and environmental factors contribute to age-dependent susceptibility to type 2 diabetes. Recent studies have reported reduced expression of PPARgamma coactivator 1alpha (PGC-1alpha) and PGC-1beta genes in skeletal muscle from type 2 diabetic patients, but it is not known whether this is an inherited or acquired defect. To address this question we studied expression of these genes in muscle biopsies...

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Source

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Identifiers

PMID: 15546003
DOI: 10.1172/JCI21889
PMCID: PMC525741

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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