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Article

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes.

Diabetes - 1 May 2004

Oberkofler Hannes, Linnemayr Veronika, Weitgasser Raimund, Klein Kerstin, Xie Mingqiang, Iglseder Bernhard, Krempler Franz, Paulweber Bernhard, Patsch Wolfgang

Abstract excerpt

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator implicated in transcriptional programs of hepatic gluconeogenesis, oxidative phosphorylation, and insulin release by beta-cells. To study associations of the PGC-1alpha gene locus with carbohydrate metabolism and type 2 diabetes in humans, we identified several polymorphisms in the promoter region that were...

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Identifiers

PMID: 15111510
DOI: 10.2337/diabetes.53.5.1385

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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