Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.

Diabetologia - 1 May 2002

Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, Kimura S, Kadowaki T

Abstract excerpt

AIMS/HYPOTHESIS: Peroxisome proliferator activated receptor gamma coactivator-1 (PGC-1), a transcriptional coactivator of the nuclear receptor PPARgamma, plays a role in adaptive thermogenesis and insulin sensitivity. Plasma fasting insulin has been linked to the chromosomal region where the PGC-1 gene is located. Thus, PGC-1 can be viewed as a functional and positional candidate for the susceptibility gene for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Glycated Hemoglobin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heat-Shock Proteins

Share to Insulin Resistance

Share to Polymorphism, Restriction Fragment Length

Share to Reference Values

Share to White People

Source

Identifiers

PMID: 12107756
DOI: 10.1007/s00125-002-0803-z

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.PMID 12107756Read ↗

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus.Semantic proximity Read ↗

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes.Semantic proximity Read ↗

The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.Semantic proximity Read ↗

A Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene is associated with type 2 diabetes in Caucasians.Semantic proximity Read ↗

Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.Semantic proximity Read ↗

Association between PGC-1alpha gene polymorphisms and type 2 diabetes risk: a case-control study of an Iranian population.Semantic proximity Read ↗

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.Semantic proximity Read ↗

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.Semantic proximity Read ↗

Association of PGC-1α gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study.Semantic proximity Read ↗

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.Semantic proximity Read ↗

Peroxisome proliferator‐activated receptor‐γ co‐activator‐1α (PGC‐1α) gene polymorphisms and their relationship to Type 2 diabetes in Asian IndiansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.