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Article

Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism.

Hormone research - 1 Jan 2007

Yamazawa Kazuki, Wada Yuka, Sasagawa Isoji, Aoki Katsuya, Ueoka Katsuhiko, Ogata Tsutomu

Abstract excerpt

BACKGROUND/AIMS: Although insulin-like factor 3 (INSL3) and its receptor leucine-rich repeat-containing G protein-coupled receptor 8/G protein-coupled receptor affecting testis descent (LGR8/GREAT) are essential for the gubernacular development, mutations of INSL3 and LGR8/GREAT are infrequent in...

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Source

Identifiers

PMID: 17028442
DOI: 10.1159/000096089

Genes

INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17028442-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism.PMID 17028442Read ↗

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism.Semantic proximity Read ↗

Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population.Semantic proximity Read ↗

Role of INSL3 and LGR8 in cryptorchidism and testicular functions.Semantic proximity Read ↗

The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.Semantic proximity Read ↗

Novel mutations involving the INSL3 gene associated with cryptorchidism.Semantic proximity Read ↗

INSL3/LGR8 role in testicular descent and cryptorchidism.Semantic proximity Read ↗

GREAT/LGR8 is the only receptor for insulin-like 3 peptide.Semantic proximity Read ↗

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization.Semantic proximity Read ↗

The G178A polymorphic variant of INSL3 may be linked to cryptorchidism among Egyptian pediatric cohort.Semantic proximity Read ↗

Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism.Semantic proximity Read ↗

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