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Article

Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.

The Journal of experimental medicine - 1 Sept 1990

Podda A, Nencioni L, De Magistris M T, Di Tommaso A, Bossù P, Nuti S, Pileri P, Peppoloni S, Bugnoli M, Ruggiero P

Abstract excerpt

PT-9K/129G, a nontoxic mutant of pertussis toxin (PT) obtained by genetic manipulation, has been shown in animal models to be a promising candidate for new vaccines against whooping cough. To assess the safety and the immunogenicity of PT-9K/129G in humans, a pilot study has been performed in adult volunteers. The protein was found to be safe, capable of inducing high titers of toxin-neutralizing antibodies, and...

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Identifiers

PMID: 2201750
DOI: 10.1084/jem.172.3.861
PMCID: PMC2188543

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Source receipt: pubmed, retrieved 7 Sept 2026.

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