Article
Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.
The Journal of experimental medicine - 1 Sept 1990
Podda A, Nencioni L, De Magistris M T, Di Tommaso A, Bossù P, Nuti S, Pileri P, Peppoloni S, Bugnoli M, Ruggiero P
Abstract excerpt
PT-9K/129G, a nontoxic mutant of pertussis toxin (PT) obtained by genetic manipulation, has been shown in animal models to be a promising candidate for new vaccines against whooping cough. To assess the safety and the immunogenicity of PT-9K/129G in humans, a pilot study has been performed in adu...
Topics
- Adult
- Antibody Formation
- Blood Glucose
- Humans
- Immunity, Cellular
- Insulin
- Killer Cells, Natural
- Leukocyte Count
- Mutation
- Pertussis Toxin
- Pertussis Vaccine
- Pilot Projects
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic
- Virulence Factors, Bordetella