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Article

Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2007

Zhang J, Matheny M K, Tümer N, Mitchell M K, Scarpace P J

Abstract excerpt

High-fat (HF) feeding induces a transient increase in caloric intake and enhances energy expenditure. We hypothesized that leptin is necessary for homeostatic restoration of the HF-enhanced caloric intake and may mediate the increase in uncoupling protein-1 (UCP1) in brown adipose tissue (BAT). W...

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Source

Identifiers

PMID: 17023670
DOI: 10.1152/ajpregu.00213.2006

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17023670-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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