Article
A putative physiological role of hypothalamic CNTF in the control of energy homeostasis.
FEBS letters - 12 Nov 2008
Vacher C-M, Crépin D, Aubourg A, Couvreur O, Bailleux V, Nicolas V, Férézou J, Gripois D, Gertler A, Taouis M
Abstract excerpt
Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight...
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