Article
Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls.
Journal of neuroimmunology - 1 Nov 2006
Gronen Felix, Ruprecht Klemens, Weissbrich Benedikt, Klinker Erdwine, Kroner Antje, Hofstetter Harald H, Rieckmann Peter
Abstract excerpt
The Epstein-Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS), however, the mechanisms by which EBV may be involved in MS are unknown. We here have investigated the frequency of EBV-specific cytotoxic T lymphocytes (CTL) in human leukocyte antigen (HLA)-B7(+) patients with MS and healthy controls using enzyme-linked immunospot assays and seven previously characterized...
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