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Article

The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis

12 Nov 2010

Abstract excerpt

There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS. This article provides a four-tier hypothesis proposing (1) EBV infection is essential for the development of MS; (2) EBV causes MS in genetically susceptible individuals by infecting autoreactive B cells, which seed the...

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PMID: 21075971
DOI: 10.1177/1073858410381531

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