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Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis

29 Mar 2006

Abstract excerpt

Epidemiological studies consistently demonstrate that patients with multiple sclerosis are almost universally infected with Epstein-Barr virus (EBV) and that the risk of developing the disease increases with the level of EBV-specific antibody titers. The EBV-encoded nuclear antigen-1 (EBNA1) maintains the viral episome in replicating infected human B cells, and EBNA1-specific CD4+ T cells have been identified as...

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PMID: 16569670
DOI: 10.1093/brain/awl067

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