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Article

Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase.

Acta clinica Belgica - 1 Oct 2014

Megens S, De Wit S, Bernatchez J, Dekeersmaeker N, Vinken L, Covens K, Theys K, Camacho R J, Vandamme A-M, Götte M, Van Laethem K

Abstract excerpt

OBJECTIVES: The amino acid position 70 in HIV-1 reverse transcriptase (RT) plays an important role in nucleoside RT inhibitor (NRTI) resistance. K70R is part of the thymidine analog mutations, but also other amino acid changes have been associated with NRTI resistance, such as K70E and K70G. In this study, we investigated the in vivo selection of the HIV-1 RT mutations K70S and K70T and their in vitro effect on...

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Identifiers

PMID: 25103592
DOI: 10.1179/2295333714Y.0000000038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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