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Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Drug metabolism and personalized therapy - 1 Dec 2016

Njuguna Nicholas M, Umehara Ken-Ichi, Huth Felix, Schiller Hilmar, Chibale Kelly, Camenisch Gian

Abstract excerpt

BACKGROUND: The fraction of an absorbed drug metabolized by the different hepatic cytochrome P450 (CYP) enzymes, relative to total hepatic CYP metabolism (fmCYP), can be estimated by measuring the inhibitory effects of presumably selective CYP inhibitors on the intrinsic metabolic clearance of a drug using human liver microsomes. However, the chemical inhibition data are often affected by cross-reactivities of...

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PMID: 27718490
DOI: 10.1515/dmpt-2016-0028

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