Article
Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: relationship to interleukin 13 gene polymorphism.
International journal of molecular medicine - 1 Nov 2006
Homma Shinsuke, Sakamoto Tohru, Hegab Ahmed E, Saitoh Wataru, Nomura Akihiro, Ishii Yukio, Morishima Yuko, Iizuka Takashi, Kiwamoto Takumi, Matsuno Yosuke, Massoud Hosam H, Massoud Hosny M, Hassanein Khalid M, Sekizawa Kiyohisa
Abstract excerpt
Activation of the cyclic AMP (cAMP) signaling pathway leads to the suppression of inflammation in the airways and relaxation of airway smooth muscle. Intracellular cAMP levels are determined by a balance between the activities of adenylate cyclase and phosphodiesterases. We hypothesized that polymorphisms of the phosphodiesterase 4D (PDE4D) gene activate its protein function which leads to the downregulation of...
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