Article
Development and comparison of a warfarin-dosing algorithm for Korean patients with atrial fibrillation.
Clinical therapeutics - 1 Oct 2011
Cho Hyun-Jung, On Young-Keun, Bang Oh Young, Kim Jong-Won, Huh Wooseong, Ko Jae-Wook, Kim June Soo, Lee Soo-Youn
Abstract excerpt
BACKGROUND: The pharmacokinetics and pharmacodynamics of warfarin are affected by polymorphisms in the genes coding for cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1). OBJECTIVE: The objective of this study was to develop a pharmacogenetic dosing algorithm for warfarin in Korean patients with atrial fibrillation and to compare it with the published pharmacogenetic dosing...
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