Article
The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2006
Montero-Balaguer Mercedes, Lang Michael R, Sachdev Sherri Weiss, Knappmeyer Christiane, Stewart Rodney A, De La Guardia Ana, Hatzopoulos Antonis K, Knapik Ela W
Abstract excerpt
The zebrafish mutation mother superior (mosm188) leads to a depletion of neural crest (NC) derivatives including the craniofacial cartilage skeleton, the peripheral nervous system (sympathetic neurons, dorsal root ganglia, enteric neurons), and pigment cells. The loss of derivatives is preceded by a reduction in NC-expressed transcription factors, snail1b, sox9b, sox10, and a specific loss of foxd3 expression in...
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