Article
Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.
Developmental biology - 1 Oct 2011
Hinits Yaniv, Williams Victoria C, Sweetman Dylan, Donn Thomas M, Ma Taylur P, Moens Cecilia B, Hughes Simon M
Abstract excerpt
Myogenic regulatory factors of the myod family (MRFs) are transcription factors essential for mammalian skeletal myogenesis. Here we show that a mutation in the zebrafish myod gene delays and reduces early somitic and pectoral fin myogenesis, reduces miR-206 expression, and leads to a persistent reduction in somite size until at least the independent feeding stage. A mutation in myog, encoding a second MRF, has...
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