Article
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study.
The Lancet. Neurology - 1 Dec 2012
Reiman Eric M, Quiroz Yakeel T, Fleisher Adam S, Chen Kewei, Velez-Pardo Carlos, Jimenez-Del-Rio Marlene, Fagan Anne M, Shah Aarti R, Alvarez Sergio, Arbelaez Andrés, Giraldo Margarita, Acosta-Baena Natalia, Sperling Reisa A, Dickerson Brad, Stern Chantal E, Tirado Victoria, Munoz Claudia, Reiman Rebecca A, Huentelman Matthew J, Alexander Gene E, Langbaum Jessica B S, Kosik Kenneth S, Tariot Pierre N, Lopera Francisco
Abstract excerpt
BACKGROUND: We have previously characterised functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's disease. To gain further knowledge on the preclinical phase of Alzheimer's disease, we sought to characterise structural and functional MRI, CSF, and plasma biomarkers in a cohort of young adults carrying a high-penetrance autosomal dominant mutation that causes early-onset...
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