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Article

Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1990

Decloître F, Lafarge-Frayssinet C, Barroso M, Lechner M C, Ouldelhkim M, Frayssinet C

Abstract excerpt

The phenotypic response of rat liver to a carcinogenic protocol involving initiation/selection and promotion with and without phenobarbital (PB) feeding was studied in pubertal and adult male rats. Considering the early presence of preneoplastic nodular areas, it appeared that pubertal rats, initiated at 6-7 weeks, presented a higher susceptibility to the protocol than adult rats initiated at 9-10 weeks. Altered...

Topics

Animals
Biomarkers, Tumor
Cytochrome P-450 Enzyme System
DNA
Glutathione Transferase
Liver Neoplasms, Experimental
Male
Phenobarbital
Phenotype
Precancerous Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Serum Albumin

alpha-Fetoproteins

gamma-Glutamyltransferase

Source

Identifiers

PMID: 1700861
DOI: 10.1159/000217665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1700861-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.PMID 1700861Read ↗

Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment.Semantic proximity Read ↗

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Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat.Semantic proximity Read ↗

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