Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.

Abstract excerpt

Airway hyperresponsiveness (AHR) is a defining feature of asthma. We have previously shown, in mice sensitized and challenged with antigen, that AHR is attributable to normal airway smooth muscle contraction with exaggerated airway closure. In the present study we sought to determine if the same was true for mice known to have intrinsic AHR, the genetic strain of mice, A/J. We found that A/J mice have AHR...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Administration, Inhalation
• Share to Bronchial Provocation Tests