Article
N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.
Stem cells (Dayton, Ohio) - 1 Jan 2007
Heiskanen Annamari, Satomaa Tero, Tiitinen Sari, Laitinen Anita, Mannelin Sirkka, Impola Ulla, Mikkola Milla, Olsson Cia, Miller-Podraza Halina, Blomqvist Maria, Olonen Anne, Salo Hanna, Lehenkari Petri, Tuuri Timo, Otonkoski Timo, Natunen Jari, Saarinen Juhani, Laine Jarmo
Abstract excerpt
Human embryonic and mesenchymal stem cell therapies may offer significant benefit to a large number of patients. Recently, however, human embryonic stem cell lines cultured on mouse feeder cells were reported to be contaminated by the xeno-carbohydrate N-glycolylneuraminic acid (Neu5Gc) and considered potentially unfit for human therapy. To determine the extent of the problem of Neu5Gc contamination for the...
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