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Article

Potential deleterious role of anti‐Neu5Gc antibodies in xenotransplantation

13 Oct 2014

Abstract excerpt

Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc antibodies in human serum. However, Neu5Gc is expressed on mammal glycoproteins and glycolipids in most organs and cells. We review here the relevance of Neu5Gc and anti-Neu5Gc antibodies...

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PMID: 25308416
DOI: 10.1111/xen.12142

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