Article

The monosialoganglioside GM1a protects trophoblasts, erythrocytes and endothelial cells against complement attack

2022-01-24

Abstract excerpt

The complement system is a part of the innate immune system in the fluid phase and efficiently eliminates pathogens. However, its activation requires tight regulation on the host cell surface in order not to compromise cellular viability. Previously, we showed that loss of placental cell surface sialylation in mice in vivo leads to a maternal complement attack at the fetal-maternal interface, ultimately resulting...

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Literature Corpus work: 5d154a52-7e90-59a8-95a5-f46ef4967f83
DOI: 10.1101/2022.01.24.477475

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