Article
Glycolipid dynamics in generation and differentiation of induced pluripotent stem cells.
Scientific reports - 19 Oct 2015
Ojima Takuma, Shibata Eri, Saito Shiho, Toyoda Masashi, Nakajima Hideki, Yamazaki-Inoue Mayu, Miyagawa Yoshitaka, Kiyokawa Nobutaka, Fujimoto Jun-Ichiro, Sato Toshinori, Umezawa Akihiro
Abstract excerpt
Glycosphingolipids (GSLs) are glycoconjugates that function as mediators of cell adhesion and modulators of signal transduction. Some well-defined markers of undifferentiated human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are glycoconjugates, such as SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81. However, Comprehensive GSL profiles of hiPSCs have not yet been elucidated. The global...
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