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Article

Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells.

The Journal of biological chemistry - 11 Feb 2005

Bardor Muriel, Nguyen Dzung H, Diaz Sandra, Varki Ajit

Abstract excerpt

N-Glycolylneuraminic acid (Neu5Gc) is a widely expressed sialic acid in mammalian cells. Although humans are genetically deficient in producing Neu5Gc, small amounts are present in human cells in vivo. A dietary origin was suggested by human volunteer studies and by observing that free Neu5Gc is metabolically incorporated into cultured human carcinoma cells by unknown mechanisms. We now show that free Neu5Gc...

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PMID: 15557321
DOI: 10.1074/jbc.M412040200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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