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Article

Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase.

The Journal of biological chemistry - 1 Dec 2006

Cobine Paul A, Pierrel Fabien, Bestwick Megan L, Winge Dennis R

Abstract excerpt

A mitochondrial matrix copper ligand (CuL) complex, conserved in mammalian cells, is the likely source of copper for assembly of cytochrome c oxidase (CcO) and superoxide dismutase 1 (Sod1) within the intermembrane space (IMS) in yeast. Targeting the copper-binding proteins human Sod1 and Crs5 to the mitochondrial matrix results in growth impairment on non-fermentable medium caused by decreased levels of CcO....

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Identifiers

PMID: 17008312
DOI: 10.1074/jbc.M606839200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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