Article
Cloned prokaryotic iron superoxide dismutase protects yeast cells against oxidative stress depending on mitochondrial location.
Biochemical and biophysical research communications - 5 Mar 1999
Balzan R, Agius D R, Bannister W H
Abstract excerpt
Superoxide dismutase (SOD) is considered to be the first line of defense against oxygen toxicity. It exists as a family of three metalloproteins with copper,zinc (Cu,ZnSOD), manganese (MnSOD), and iron (FeSOD) forms. In this work, we have targeted Escherichia coli FeSOD to the mitochondrial intermembrane space (IMS) of yeast cells deficient in mitochondrial MnSOD. Our results show that FeSOD in the IMS increases...
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