Article

A genome wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

2021-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Copper is essential for the activity and stability of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain. Loss-of-function mutations in genes required for copper transport to CcO result in fatal human disorders. Despite the fundamental importance of copper in mitochondrial and organismal physiology, systematic characterization of genes that regulate mitochond...

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Literature Corpus work: ca01b8a1-f08a-5daa-8780-147aba496859
DOI: 10.1101/2020.12.31.424969

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