Article
Overlap of copper and iron uptake systems in mitochondria in Saccharomyces cerevisiae.
Open biology - 1 Jan 2016
Vest Katherine E, Wang Jing, Gammon Micah G, Maynard Margaret K, White Olivia L, Cobine Jai A, Mahone Wilkerson K, Cobine Paul A
Abstract excerpt
In Saccharomyces cerevisiae, the mitochondrial carrier family protein Pic2 imports copper into the matrix. Deletion of PIC2 causes defects in mitochondrial copper uptake and copper-dependent growth phenotypes owing to decreased cytochrome c oxidase activity. However, copper import is not completely eliminated in this mutant, so alternative transport systems must exist. Deletion of MRS3, a component of the iron...
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