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Quantification of radiation-induced DNA double strand break repair foci to evaluate and predict biological responses to ionizing radiation

4 Oct 2021

Abstract excerpt

Abstract Radiation-induced foci (RIF) are nuclear puncta visualized by immunostaining of proteins that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF are a standard metric for measuring DSB formation and repair in clinical, environmental and space radiobiology. The time course and dose dependence of their formation has great potential to predict in vivo responses to...

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PMID: 35692378
DOI: 10.1093/narcan/zcab046

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