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Article

Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.

The Journal of biological chemistry - 29 Jul 2005

Kothe Michael, Ye Yihong, Wagner Jessica S, De Luca Heidi E, Kern Eli, Rapoport Tom A, Lencer Wayne I

Abstract excerpt

The enzymatic A1 chain of cholera toxin retrotranslocates across the endoplasmic reticulum membrane into the cytosol, where it induces toxicity. Almost all other retrotranslocation substrates are modified by the attachment of polyubiquitin chains and moved into the cytosol by the ubiquitin-interacting p97 ATPase complex. The cholera toxin A1 chain, however, can induce toxicity in the absence of ubiquitination,...

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Source

Identifiers

PMID: 15932873
DOI: 10.1074/jbc.M503138200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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