Article

Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease

2024-10-21

Abstract excerpt

Fibrosis is the cause of end-stage kidney failure in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The molecular and cellular mechanisms involved in fibrosis are complex and anti-fibrotic therapies have so far failed to make an impact on patient welfare. Using unbiased proteomics analysis on the Pkd1 nl/nl mouse, we found that expression of the integrin α1 subunit is increased in this model...

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Literature Corpus work: 5241ccfe-a4c2-5bfa-b000-eb96e57a624b
DOI: 10.1101/2024.10.18.619080

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