Article
Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.
Journal of virology - 1 Jun 1992
Martínez M A, Dopazo J, Hernández J, Mateu M G, Sobrino F, Domingo E, Knowles N J
Abstract excerpt
The genetic diversification of foot-and-mouth disease virus (FMDV) of serotype C over a 6-decade period was studied by comparing nucleotide sequences of the capsid protein-coding regions of viruses isolated in Europe, South America, and The Philippines. Phylogenetic trees were derived for VP1 and P1 (VP1, VP2, VP3, and VP4) RNAs by using the least-squares method. Confidence intervals of the derived phylogeny...
Topics
- Amino Acid Sequence
- Antigenic Variation
- Aphthovirus
- Biological Evolution
- Capsid
- Genes, Viral
- Molecular Sequence Data
- Mutation
- Sequence Homology, Nucleic Acid
- Serotyping
