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Article

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.

Journal of virology - 1 Jun 1992

Martínez M A, Dopazo J, Hernández J, Mateu M G, Sobrino F, Domingo E, Knowles N J

Abstract excerpt

The genetic diversification of foot-and-mouth disease virus (FMDV) of serotype C over a 6-decade period was studied by comparing nucleotide sequences of the capsid protein-coding regions of viruses isolated in Europe, South America, and The Philippines. Phylogenetic trees were derived for VP1 and P1 (VP1, VP2, VP3, and VP4) RNAs by using the least-squares method. Confidence intervals of the derived phylogeny...

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Identifiers

PMID: 1316467
DOI: 10.1128/JVI.66.6.3557-3565.1992
PMCID: PMC241137

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Source receipt: pubmed, retrieved 7 Sept 2026.

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