Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire.

Immunogenetics - 1 Jan 2006

Lee C E H, Gaëta B, Malming H R, Bain M E, Sewell W A, Collins A M

Abstract excerpt

We have used a bioinformatics approach to evaluate the completeness and functionality of the reported human immunoglobulin heavy-chain IGHD gene repertoire. Using the hidden Markov-model-based iHMMune-align program, 1,080 relatively unmutated heavy-chain sequences were aligned against the reported repertoire. These alignments were compared with alignments to 1,639 more highly mutated sequences. Comparisons of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Databases, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genes, Immunoglobulin

Share to Immunoglobulin Heavy Chains

Share to Markov Chains

Share to Point Mutation

Share to Sequence Alignment

Source

Identifiers

PMID: 16402215
DOI: 10.1007/s00251-005-0062-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire.PMID 16402215Read ↗

Many human immunoglobulin heavy-chain IGHV gene polymorphisms have been reported in error.Semantic proximity Read ↗

Poorly expressed alleles of several human immunoglobulin heavy chain variable (IGHV) genes are common in the human populationSemantic proximity Read ↗

Poorly Expressed Alleles of Several Human Immunoglobulin Heavy Chain Variable Genes are Common in the Human Population.Semantic proximity Read ↗

iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequencesSemantic proximity Read ↗

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.Semantic proximity Read ↗

Identifying highly mutated IGHD genes in the junctions of rearranged human immunoglobulin heavy chain genes.Semantic proximity Read ↗

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region LocusSemantic proximity Read ↗

A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies.Semantic proximity Read ↗

Immunoglobulin gene alterations in human heavy chain diseases.Semantic proximity Read ↗

Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains.Semantic proximity Read ↗

The Complete Map of the Ig Heavy Chain Constant Gene Region Reveals Evidence for Seven IgG Isotypes and for IgD in the HorseSemantic proximity Read ↗

Exonuclease activity and P nucleotide addition in the generation of the expressed immunoglobulin repertoire.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.