Article
Monoreactive and polyreactive rheumatoid factors produced by in vitro Epstein-Barr virus-transformed peripheral blood and synovial B lymphocytes from rheumatoid arthritis patients.
Scandinavian journal of immunology - 1 Oct 1990
Burastero S E, Cutolo M, Dessì V, Celada F
Abstract excerpt
The CD5 membrane molecule, initially identified as an exclusive T-cell marker, also defines a phenotypically and functionally distinct B-lymphocyte population. In normal individuals, CD5+ B cells are committed to secrete 'natural' polyreactive (auto)antibodies, that is antibodies, mainly IgM, endowed with multiple antigen-binding capabilities, including rheumatoid factor (RF) activity. At variance with this, in...
Topics
- Adult
- Aged
- Antigens, Differentiation
- Arthritis, Rheumatoid
- B-Lymphocyte Subsets
- CD5 Antigens
- Cell Line, Transformed
- Cell Transformation, Viral
- Female
- Flow Cytometry