Article
Do naturally occurring autoantibodies participate in the constitution of the pathological B-cell repertoire in systemic lupus erythematosus?
Journal of autoimmunity - 1 Apr 1996
Gilbert D, Brard F, Jovelin F, Tron F
Abstract excerpt
Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune diseases. In both human and mouse SLE diseases, the autoimmune response targets a restricted set of autoantigens. Many of them are nucleic acids and proteins involved in the synthesis and processing of DNA or RNA, a charac...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Autoantibodies
- Autoimmunity
- B-Lymphocytes
- Humans
- Immune Tolerance
- Lupus Erythematosus, Systemic
- Mutation