Article
Rheumatoid arthritis synovial fluid shows enrichment of T-cells producing GMCSF which are polyfunctional for TNFα and IFNγ.
Clinical and experimental rheumatology - 1 Jul 2024
Khullar Aastha, Dhir Varun, Saikia Biman, Yadav Ashok Kumar, Leishangthem Bidyalaxmi, Prasad Chandra Bhushan, Jayaprakash Sankar, Jain Siddharth, Naidu G S R S N K, Sharma Shefali K, Sharma Aman, Jain Sanjay
Abstract excerpt
OBJECTIVES: GMCSF+T-cells may be involved in pathogenesis of rheumatoid arthritis (RA), and polyfunctionality may be a marker of pathogenicity. Although, higher frequencies of CD4+GMCSF+ T-cells have been reported, there are no data on CD8+GMCSF+ T-cells or polyfunctionality.Our objective was to enumerate frequencies of CD8+GMCSF+ T cells in RA blood and synovial fluid (SF), and assess their polyfunctionality,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.