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Article

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.

Diabetes - 1 Oct 2006

Onengut-Gumuscu Suna, Buckner Jane H, Concannon Patrick

Abstract excerpt

A recent addition to the list of widely confirmed type 1 diabetes risk loci is the PTPN22 gene encoding a lymphoid-specific phosphatase (Lyp). However, evidence supporting a role for PTPN22 in type 1 diabetes derives entirely from the study of just one coding single nucleotide polymorphism, 1858C/T. In the current study, the haplotype structure of the PTPN22 region was determined, and individual haplotypes were...

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Share to Diabetes Mellitus, Type 1
Share to PTPN22 gene
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 17003357
DOI: 10.2337/db06-0225

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.PMID 17003357Read ↗

Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.Semantic proximity Read ↗

Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.Semantic proximity Read ↗

C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.Semantic proximity Read ↗

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.Semantic proximity Read ↗

PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.Semantic proximity Read ↗

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.Semantic proximity Read ↗

A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families.Semantic proximity Read ↗

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.Semantic proximity Read ↗

Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.Semantic proximity Read ↗

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.Semantic proximity Read ↗

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.Semantic proximity Read ↗

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