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Article

Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.

Human immunology - 1 Jan 2005

Ladner Martha B, Bottini Nunzio, Valdes Ana M, Noble Janelle A

Abstract excerpt

The PTPN22 (protein tyrosine phosphatase N22) gene encodes the protein tyrosine phosphatase Lyp. One function of Lyp is downregulation of T-cell signaling through its interaction with the negative regulatory kinase C-terminal Src tyrosine kinase (Csk). A single nucleotide polymorphism in the PTPN22 gene, C1858T, encodes products with different Csk binding affinities. Disease association of the PTPN22 1858T allele...

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Share to Diabetes Mellitus, Type 1
Share to PTPN22 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 15620463
DOI: 10.1016/j.humimm.2004.09.016

Genes

PTPN22
TCF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.PMID 15620463Read ↗

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