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Article

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP.

The Journal of biological chemistry - 20 Dec 2002

Borgius Lotta Johansson, Steffensen Knut R, Gustafsson Jan-Ake, Treuter Eckardt

Abstract excerpt

SHP (NROB2) is an atypical orphan nuclear receptor that lacks a DNA-binding domain but contains a putative ligand-binding domain. Previous studies have revealed that SHP interacts with a variety of nuclear receptors and inhibits their transcriptional activity, thereby acting as a corepressor. In this report we identify the glucocorticoid receptor (GR) as a novel downstream target receptor for SHP inhibition. SHP...

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Identifiers

PMID: 12324453
DOI: 10.1074/jbc.M205641200

Genes

PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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