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Article

Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.

The Journal of biological chemistry - 16 Nov 2001

Wallace A D, Cidlowski J A

Abstract excerpt

Ligand-dependent down-regulation of the glucocorticoid receptor (GR) has been shown to limit hormone responsiveness, but the mechanisms involved in this process are poorly understood. The glucocorticoid receptor is a phosphoprotein that upon ligand binding becomes hyperphosphorylated, and recent evidence indicates that phosphorylation status of the glucocorticoid receptor plays a prominent role in receptor...

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PMID: 11555652
DOI: 10.1074/jbc.M106033200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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