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Non‐genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease

2 Nov 2021

Abstract excerpt

Observational epidemiological studies have associated vitamin D deficiency with Alzheimer's disease (AD). However, whether vitamin D deficiency would result in some impacts on the vitamin D binding receptor (VDR) remains to be characterized in AD. Vitamin D helps maintain adult brain health genomically through binding with and activating a VDR/retinoid X receptor (RXR) transcriptional complex. Thus, we...

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PMID: 34725922
DOI: 10.1111/acel.13509

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