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Article

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.

The Journal of clinical investigation - 1 Aug 1995

Knoerzer D B, Karr R W, Schwartz B D, Mengle-Gaw L J

Abstract excerpt

Antigen-specific T cell activation requires two independent signalling events, one mediated through T cell receptor engagement by the antigen-presenting cell-expressed peptide/class II major histocompatibility complex, and the second through the cognate interactions of costimulatory molecules expressed on the T cell and antigen-presenting cell. There is evidence from in vitro and in vivo experimental systems...

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Identifiers

PMID: 7543497
DOI: 10.1172/JCI118146
PMCID: PMC185286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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