Article
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.
The Journal of clinical investigation - 1 Aug 1995
Knoerzer D B, Karr R W, Schwartz B D, Mengle-Gaw L J
Abstract excerpt
Antigen-specific T cell activation requires two independent signalling events, one mediated through T cell receptor engagement by the antigen-presenting cell-expressed peptide/class II major histocompatibility complex, and the second through the cognate interactions of costimulatory molecules exp...
Topics
- Abatacept
- Animals
- Antigens, CD
- Antigens, Differentiation
- Arthritis, Rheumatoid
- Autoantibodies
- Autoimmune Diseases
- B7-1 Antigen
- Base Sequence
- CD28 Antigens
- CTLA-4 Antigen
- Cartilage, Articular
- Cattle
- Collagen
- Disease Models, Animal
- Disease Susceptibility
- Genetic Predisposition to Disease
- Hypersensitivity, Delayed