Laminin 332 in junctional epidermolysis bullosa

doi:10.4161/cam.22418

Article

Laminin 332 in junctional epidermolysis bullosa

1 Jan 2013

Abstract excerpt

Laminin 332 is an essential component of the dermal-epidermal junction, a highly specialized basement membrane zone that attaches the epidermis to the dermis and thereby provides skin integrity and resistance to external mechanical forces. Mutations in the LAMA3, LAMB3 and LAMC2 genes that encode the three constituent polypeptide chains, α3, β3 and γ2, abrogate or perturb the functions of laminin 332. The...

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