Article
No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.
Diabetes research and clinical practice - 1 May 2007
Cinek Ondrej, Hradsky Ondrej, Ahmedov Gunduz, Slavcev Antonij, Kolouskova Stanislava, Kulich Michal, Sumnik Zdenek
Abstract excerpt
INTRODUCTION: The PTPN22 is a negative regulator of the T cell response. Its +1858C>T (R620W) polymorphism has been shown to associate with a risk for multiple autoimmune diseases, including type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). The minor (susceptibility) allele is absent in Asian populations, but a recent study suggested an independent involvement of another polymorphism located within...
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