Article
Genomic diversity and antigenic variation of HIV-1: links between pathogenesis, epidemiology and vaccine development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1991
Goudsmit J, Back N K, Nara P L
Abstract excerpt
Recent analysis of primate lentivirus genomes indicates that lentiviruses have infected primates for hundreds of years. The pathogenicity of such viruses may fluctuate due to the high evolution rate of some parts of the viral genome. Fixed nucleic acid substitutions in the gag gene appear to be c...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Antigenic Variation
- Genes, env
- Genes, gag
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Transcription, Genetic
- Viral Vaccines