Loss of encephalitogenicity of a myelin basic protein-specific T cell line is associated with a phenotypic change but not with alteration in production of interleukin-2, gamma-interferon or tumour necrosis factor.

Abstract excerpt

Continued stimulation of a CD4+ myelin basic protein-specific T cell line led to loss of in vivo encephalitogenic activity but no alteration in ability of the line to produce interleukin-2, gamma-interferon or tumour necrosis factor. Loss of encephalitogenicity was, however, associated with an increased presence of CD4+ CD8+ cells which likely represents preferential outgrowth of this population. The possible in...

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