Loss of encephalitogenicity of a myelin basic protein-specific T cell line is associated with a phenotypic change but not with alteration in production of interleukin-2, gamma-interferon or tumour necrosis factor.

Abstract excerpt

Continued stimulation of a CD4+ myelin basic protein-specific T cell line led to loss of in vivo encephalitogenic activity but no alteration in ability of the line to produce interleukin-2, gamma-interferon or tumour necrosis factor. Loss of encephalitogenicity was, however, associated with an in...

Topics

• Animals
• Cell Line
• Encephalomyelitis, Autoimmune, Experimental
• Female
• Interferon-gamma
• Interleukin-2
• Male
• Myelin Basic Protein
• Phenotype
• Rats
• Rats, Inbred Lew
• T-Lymphocytes
• Tumor Necrosis Factor-alpha