Article
Oligodendrocyte lysis by CD4+ T cells independent of tumor necrosis factor.
Annals of neurology - 1 Mar 1994
Antel J P, Williams K, Blain M, McRea E, McLaurin J
Abstract excerpt
The capacity of human CD4+ T cells to lyse heterologous human oligodendrocytes in an 18-hour chromium 51-release assay was compared to that of systemic blood-derived macrophages and central nervous system-derived microglia. CD4+ T cells, activated with either phytohemagglutinin, anti-CD3 antibody...
Topics
- Adult
- CD4-Positive T-Lymphocytes
- Cytotoxicity, Immunologic
- Humans
- In Vitro Techniques
- Macrophages
- Microglia
- Mitogens
- Myelin Basic Protein
- Oligodendroglia
- Phenotype
- Tumor Necrosis Factor-alpha