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Article

Antigen processing of myelin basic protein is required prior to recognition by T cells inducing EAE.

Cellular immunology - 1 Aug 1990

Cross A H, Dolich S, Raine C S

Abstract excerpt

The processing and presentation of whole myelin basic protein (MBP) and a 12 amino acid encephalitogenic peptide were investigated using MBP-immune and peptide-immune murine T cell lines. Myelin basic protein is the major component of central nervous system (CNS) white matter capable of inciting an autoimmune response which leads to the disease, experimental allergic encephalomyelitis (EAE), in a number of animal...

Topics

Amino Acid Sequence
Animals
Antigen-Presenting Cells
Encephalomyelitis, Autoimmune, Experimental
Female
Immunization, Passive
Lymphocyte Activation
Mice
Molecular Sequence Data
Myelin Basic Protein
Peptide Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protease Inhibitors

Protein Processing, Post-Translational

T-Lymphocytes

Time Factors

Source

Identifiers

PMID: 1694732
DOI: 10.1016/0008-8749(90)90183-r

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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