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Article

Role of CD8 <sup>+</sup> T Cells in Murine Experimental Allergic Encephalomyelitis

22 May 1992

Abstract excerpt

The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to...

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PMID: 1375398
DOI: 10.1126/science.256.5060.1213

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