Article
Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice.
Development (Cambridge, England) - 1 Sept 2002
Hide Takuichiro, Hatakeyama Jun, Kimura-Yoshida Chiharu, Tian E, Takeda Naoki, Ushio Yukitaka, Shiroishi Toshihiko, Aizawa Shinichi, Matsuo Isao
Abstract excerpt
Mice heterozygous for the Otx2 mutation display a craniofacial malformation, known as otocephaly or agnathia-holoprosencephaly complex. The severity of the phenotype is dependent on the genetic background of a C57BL/6 (B6) strain; most of the offspring of Otx2 knock-out chimeras, which are equivalent to the F(1) of CBA and B6 strains, backcrossed with B6 females display reduction or loss of mandible, whereas...
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